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Submitted: 27 Dec 2020
Accepted: 18 Mar 2021
ePublished: 30 Mar 2021
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Dis Diagn. 2021;10(1): 19-22.
doi: 10.34172/ddj.2021.04
  Abstract View: 529
  PDF Download: 242

Case Report

Job’s Syndrome With a Family History of Kawasaki Disease: A Case Presentation and Review of Literature

Tamar Yared 1* ORCID logo, Samer Mohsen 1,2 ORCID logo

1 Department of Otolaryngology, Faculty of Medicine, Damascus University, Damascus, Syria
2 Department of Audiology, Faculty of Health Sciences, Damascus University, Damascus, Syria
*Correspondence to Tamar Yared, Department of Otolaryngology, Faculty of Medicine, Damascus University, Damascus, Syria. Tel: +963-955182529, Email: samer_yn@yahoo. com

Abstract

Background: Job’s syndrome or hyper-immunoglobulin E (IgE) syndrome (HIES) is an extremely rare primary immunodeficiency disease with an approximate annual incidence of less than 1/1000000. It is characterized by recurrent cold staphylococcal infections, unusual eczematous dermatitis, severe lung infections, and extensively high concentrations of the serum antibody IgE.

Case Presentation: A typical case of Job’s syndrome with a family history of Kawasaki disease is presented in this study aiming at identifying the clinical features, investigational procedures, and management strategy, as well as evaluating the role of the ear, nose, and throat specialist and highlighting the probable relation between Job’s syndrome and Kawasaki disease.

Conclusions: In general, early detection with proper care can prevent the progression of Job syndrome. In addition, the initiated treatment at the first signs of infection is mandatory for preventing long-term complications. There is a probable relation between Job and Kawasaki which requires more consideration.

Keywords: Job’s syndrome, Kawasaki, Neck mass, Hyper-immunoglobulin E syndrome, Primary immunodeficiency
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