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Submitted: 09 Mar 2021
Accepted: 19 Mar 2021
ePublished: 30 Mar 2021
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Dis Diagn. 2021;10(1): 29-35.
doi: 10.34172/ddj.2021.06
  Abstract View: 206
  PDF Download: 191

Original Article

Evaluating the Correlation of Hemostatic and Endocrine Parameters with Child-Turcotte-Pugh Scoring in Patients with Non-Alcoholic Liver Cirrhosis

Harun Düğeroğlu 1* ORCID logo, Mustafa Yılmaz 2 ORCID logo

1 Department of Internal Medicine, Ordu University Faculty of Medicine, Ordu, Turkey.
2 Sivas State Hospital, Clinic of Internal Medicine, Sivas, Turkey.
*Correspondence to Harun Düğeroğlu, Department of Internal Medicine, Ordu University Faculty of Medicine, Ordu, Turkey. Tel: +0905304641575, Email: harun.dugeroglu@ hotmail.com

Abstract

Background: Liver cirrhosis is one of the most significant causes of death in many regions worldwide. This study aimed to assess the correlation of hemostatic and endocrine parameters with Child-Turcotte-Pugh (CTP) scoring in patients with non-alcoholic liver cirrhosis.

Materials and Methods: This study included 59 patients monitored for non-alcoholic liver cirrhosis in a gastroenterology clinic from January 2018 to February 2019. The subjects were grouped according to the CTP scores, and their adrenocorticotropic hormone (ACTH), cortisol, dehydroepiandrosterone sulfate (DHEA-SO4), progesterone, growth hormone (GH), insulin-like growth factor-1 (IGF-1), GH/ IGF-1 ratio, fibrinogen, D-dimer, and D-dimer/fibrinogen ratio were measured.

Results: According to CTP scoring, 20.3% of patients were CTP-A (n=12), 35.6% were CTP-B (n=21), and 44.1% were CTP-C (n=26). There were statistically significant differences for IGF-1, DHEA-SO4, and GH/IGF-1 ratios between CTP-A and CTP-B groups (P=0.002, P=0.043, P=0.038, respectively). Additionally, there were statistically significant differences between the CTP-B and CTP-C groups for D-dimer and GH values (P=0.024, P=0.006, respectively). There were statistically significant differences for D-dimer, GH, IGF-1, and D-dimer/fibrinogen ratio between the CTP-A and CTP-C groups (P<0.001, P=0.016, P=0.002, P=0.031, respectively).

Conclusion: Severe hemostatic and endocrine complications develop in patients with liver cirrhosis due to non-alcoholic causes. Additionally, it seems that using D-dimer and D-dimer/fibrinogen ratio, along with fibrinogen level, can be beneficial in showing liver damage in these patients.

Keywords: Non-alcohol-related liver cirrhosis, Child-Turcotte-Pugh score, D-dimer, Fibrinogen, D-dimer/fibrinogen ratio
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