Logo-ddj
Submitted: 08 Oct 2020
Accepted: 06 Dec 2020
ePublished: 30 Dec 2020
EndNote EndNote

(Enw Format - Win & Mac)

BibTeX BibTeX

(Bib Format - Win & Mac)

Bookends Bookends

(Ris Format - Mac only)

EasyBib EasyBib

(Ris Format - Win & Mac)

Medlars Medlars

(Txt Format - Win & Mac)

Mendeley Web Mendeley Web
Mendeley Mendeley

(Ris Format - Win & Mac)

Papers Papers

(Ris Format - Win & Mac)

ProCite ProCite

(Ris Format - Win & Mac)

Reference Manager Reference Manager

(Ris Format - Win only)

Refworks Refworks

(Refworks Format - Win & Mac)

Zotero Zotero

(Ris Format - Firefox Plugin)

Disease and Diagnosis. 2020;9(4): 140-143.
doi: 10.34172/ddj.2020.02
  Abstract View: 24
  PDF Download: 12

Original Article

The Association of Thyroid Hormones With β-HCG in Patients With Hydatidiform Mole

Hamid Reza Samimagham 1 ORCID logo, Shirin Mehraban 1, Marzieh Nikparvar 2 ORCID logo, Mohsen Arabi 3 ORCID logo, Elham Boushehri 4, Mitra Kazemi Jahromi 1* ORCID logo

1 Clinical Research Development Center, Shahid Mohammadi Hospital, Hormozgan University of Medical Sciences, Bandar Abbas, Iran.
2 Cardiovascular Research Center, Hormozgan University of Medical Sciences, Bandar Abbas, Iran.
3 Department of Family Medicine, Iran University of Medical Sciences, Tehran, Iran.
4 Medical Education Department, Health School, Hormozgan University of Medical Sciences, Bandar Abbas, Iran.
*Correspondence to Mitra KazemiJahromi, Clinical Research Development Center, Shahid Mohammadi Hospital, Hormozgan University of Medical Sciences, Bandar Abbas, Iran. Tell:+989177912820; Email: mitra. kazemijahromi@gmail.com

Abstract

Background: A hydatidiform mole or molar pregnancy is the most prevalent gestational trophoblastic disease (GTD). About 55%-60% of women with trophoblastic diseases have overt hyperthyroidism at the time of diagnosis, which may have severe manifestations. This study examined the relationship between gestational hypertension and the level of thyroid hormones with beta human chorionic gonadotropin (β-HCG) in patients with a hydatidiform mole.

Materials and Methods: This cross-sectional study enrolled 65 patients with a hydatidiform mole admitted to Khalij-e Fars hospital, Bandar Abbas, Iran. Patients were divided into three groups of clinical hyperthyroidism, subclinical hyperthyroidism, and healthy. The serum levels of thyroid-stimulating hormone (TSH), T4, T3, and β-HCG were checked in all subjects, and the relationship between gestational hypertension and the level of thyroid hormones with β-HCG in patients with a hydatidiform mole was examined.

Results: The mean age of patients was 29.93 ± 9.04 years, and their mean gestational age was 11.09 ± 4.2 weeks. In this study, 12.3% of the patients had subclinical hyperthyroidism, 41.5% had clinical hyperthyroidism, and 46.2% were healthy. A significant relationship was found between the serum level of β-HCG and thyroid function in patients with clinical and subclinical hyperthyroidism compared to the healthy group (P= 0.001). No significant relationship was found between systolic/ diastolic blood pressure and the serum level of β-HCG.

Conclusion: A significant relationship was observed between the serum levels of β-HCG and TSH, free T3, and free T4 in patients with a hydatidiform mole and thyrotoxicosis. Thus, early diagnosis of hyperthyroidism can help treat these patients more quickly.

Keywords: Hydatidiform mole, Thyroid hormone, β-HCG

First Name
 
Last Name
 
Email Address
 
Comments
 
Security code


Abstract View: 24

Your browser does not support the canvas element.


PDF Download: 12

Your browser does not support the canvas element.