Logo-ddj
Submitted: 06 Nov 2019
Accepted: 07 Dec 2019
ePublished: 15 Dec 2019
EndNote EndNote

(Enw Format - Win & Mac)

BibTeX BibTeX

(Bib Format - Win & Mac)

Bookends Bookends

(Ris Format - Mac only)

EasyBib EasyBib

(Ris Format - Win & Mac)

Medlars Medlars

(Txt Format - Win & Mac)

Mendeley Web Mendeley Web
Mendeley Mendeley

(Ris Format - Win & Mac)

Papers Papers

(Ris Format - Win & Mac)

ProCite ProCite

(Ris Format - Win & Mac)

Reference Manager Reference Manager

(Ris Format - Win only)

Refworks Refworks

(Refworks Format - Win & Mac)

Zotero Zotero

(Ris Format - Firefox Plugin)

Int Electron J Med. 2019;8(2): 135-139.
doi: 10.34172/iejm.2019.11
  Abstract View: 921
  PDF Download: 463

Review Article

Role of Free Radical-induced Oxidative Stress in the Pathogenesis of Coronary Artery Disease

Reza Alipoor 1 ORCID logo, Mahta Moraghebi 1 ORCID logo, Hossein Abbasi 1 ORCID logo, Ebrahim Eftekhar 2* ORCID logo

1 Student Research Committee, Hormozgan University of Medical Sciences, Bandar Abbas, Iran.
2 Molecular Medicine Research Center, Hormozgan Health Institute, Hormozgan University of Medical Sciences, Bandar Abbas, Iran.
*Corresponding Author: *Correspondence to Ebrahim Eftekhar, Molecular Medicine Research Center, Hormozgan Health Institute, Hormozgan University of Medical Sciences, Bandar Abbas, Iran. Tel: +987633354939 Email: , Email: eftekhar19@gmail.com

Abstract

Oxidative stress is associated with various pathophysiological events such as cancer, kidney diseases, and diabetes. Studies have shown that reactive oxygen species (ROS) also play a key role in the development of vasculopathies and can cause disorders such as atherosclerosis, hypertension, and coronary stenosis. Atherosclerosis, due to endothelial cell damage, results in at least impaired endothelial function and consequently macrophage infiltration and impaired smooth muscle function. Since then, many researchers have focused on low-density lipoprotein (LDL) oxidation and its interaction with the endothelium as the primary injury that leads to the formation of fatty streaks and eventually to atherogenesis. It has now become clear that different types of ROS are not only produced in the vessel wall but also contribute to the pathogenesis of a range of cardiovascular disorders individually and collectively.
First Name
 
Last Name
 
Email Address
 
Comments
 
Security code


Abstract View: 922

Your browser does not support the canvas element.


PDF Download: 463

Your browser does not support the canvas element.