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Submitted: 04 Sep 2020
Accepted: 21 Sep 2020
ePublished: 30 Dec 2020
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  Abstract View: 56

Review Article

COVID-19 Treatments Based on Pathogenicity

Ali Salimi Asl 1 ORCID logo, Faezeh Malekzadeh 2 ORCID logo, Amin Reza Nikpoor 3 ORCID logo, Shaghayegh Kermani Nezhad 1* ORCID logo, Sobhan Montazerghaem 1* ORCID logo

1 Student Research Committee, Faculty of Medicine, Hormozgan University of Medical Sciences, Bandar Abbas, Iran.
2 Student Research Committee, Faculty of Paramedicine, Hormozgan University of Medical Sciences, Bandar Abbas, Iran.
3 Department of Immunology, Faculty of Medicine, Hormozgan University of Medical Science, Bandar Abbas, Iran.
*Correspondence to Shaghayegh Kermaninezhad, Tel: +98 938 2388117; Email: Shaghayegh.krmn@ gmail.com Sobhan Montazerghaem, Tel: +98 913 3508414; Email: Shaghayegh.krmn@ gmail.com

Abstract

The new coronavirus was first identified in China in December 2019 and then, it created a widespread pandemic around the world. There is currently no definitive cure for it and it will not be possible to make a vaccine soon. Pathogenic mechanism of the virus includes virus entry, binding to angiotensin-converting enzyme 2 (ACE2) receptors on the surface of host cells, proliferation, membrane fusion, assembly, subsequent infection, cytokine secretion, and the host immune response to the virus. By identifying at what stage the patient is, possible effective drugs can be used to control each stage. Therefore, identifying the mechanism of action of the virus in different stages of the disease makes it possible to use the appropriate drug for each stage of the disease and control the disease.
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